Studies have shown that an accumulation of critically short telomeres causes more rapid aging. Interventions that decrease the rate of telomere shortening with age, such as enhancing telomerase, can delay aging and increase longevity. Thus, therapeutic strategies based on telomerase activation are envisioned as potentially important for intervening in age related problems.
What is Aging?
Ageing (British English) or aging (American English) is just the process of becoming older. The term is used to refer to biological aging of human beings, animals and other organisms, but can also refer to individual cells within an organism (cellular aging) or to the population of a species (population aging).
In humans, aging is an accumulation of changes over time, encompassing physical, psychological, and social change. Reaction time may slow with age, while knowledge and wisdom may expand. Aging is one of the greatest contributing risk factors for most human diseases, and of the roughly 150,000 people who die each day across the globe, about two thirds die from age-related causes.
The causes of aging can be ascribed to damage, whereby the accumulation of externally induced damage (such as DNA point mutations) may cause biological systems to fail, or to programmed aging, whereby internal processes (such as DNA telomere shortening) may cause aging.
Telomere-shortening can be seen as a programmed aging ‘disease’ and could be cured by lengthening telomeres via Telomerase Induction.
Defytime proposes 2 different Telomerase Induction methods:
Anti-aging Therapeutic used in creams, supplements, and drugs
Hybrid Vector Solution (injection of a virus), available in our clinic in Vanuatu for VVIP patients.
Telomerase Induction Method 1
Telomerase can be naturally produced by your cells to repair telomeres, but this function is shut off by a repressor protein binding to a regulator site or ‘switch’ on the chromosome.
Defytime introduces a therapeutic element that binds to the repressor protein. This prevents the repressor protein from binding to the regulator site, allowing telomerase production to be activated.
The telomerase produced by your cells can then repair the portions of the telomeres lost in cell division.
Hybrid Vector Solution
Telomerase Induction Method 2
In Defytime Telomere Lengthening Therapy, a hybrid vector combining the activated human telomerase gene and AAV is made and cultured.
The hybrid vector is basically intravenously injected* so that it can be transported to target tissue and delivered into cells via the blood. In the cells, the hybrid vector causes telomerase to be expressed, which restores shortened telomeres.
*The administration method may be changed to suit the patient (target tissue).