Clinical trials in vivo in Italy of TAM C0314818 were carried out over 30 days in order to evaluate its anti-wrinkle efficacy and capability in improving the skin elasticity and firmness on 100 healthy female volunteers aged from 36 to 65.

TAM C0314818 has demonstrated strong anti-aging properties, providing excellent improvement of skin condition over 30 days.

  • 100 women tested, 36-65 years old
  • Applied twice daily, 20ug/ml TAM C0314818
  • Tested on day 0, 15, 30

The following parameters were investigated:

  1. Morphological analysis of the crow’s feet and forehead treated areas by the means of an in-vivo-3D-Scanner DermaTOP-Blue (Eotech, France) dedicated to no contact local measurement of the skin surface topography.
  2. Skin elasticity and firmness instrumentally evaluated by means of Cutometer® (Courage-Khazaka GmbH, Germany).

The measurements with DermaTOP-Blue were carried out on the crow’s feet area and on the forehead before (0 days) and after 15 and 30 days of bi-daily application of the product.

The measurements with Cutometer® were carried out on the volar surface of the right and left forearm before (0 days) and after 15 and 30 days of bi-daily application of the product. The right forearm was treated with the product while the left one remained untreated for all the study duration (negative control area).

Moreover at the end of the study all the participants filled in a questionnaire relative to a subjective evaluation of the cosmetic pleasantness, of the perception of efficacy and to a general satisfaction of the product and its performance.

The study was performed at the Abich S.r.l. Clinical and Cosmetological Trials Center in Vimodrone (Milan), Italy, in cooperation with San Raffaele Hospital.

The experimentation started the 27th February, 2014 and ended the 12th May, 2014.

Here are some of the most representative images of the improvement of skin roughness in the treated areas before the beginning and at the end of the study after 30 days of bi-daily product usage.

Representative images extrapolated from DermaTOP-Blue software showing the improvement of skin roughness after 30 days.

The 100 subjects who took part in the study answered a questionnaire on a subjective evaluation of the tested product.

The questions of the questionnaire and their answers are represented in the form of graphs. The mean values on the VAS scale or the percentage of volunteers who expressed the same opinion were calculated for each answer.

How long after the first application have you noticed an improvement in skin roughness?

How long after the first application have you noticed an improvement in skin hydration?

After the product usage did you note adverse effects caused by the product itself (irritation, itching, burning sensation, redness, etc…)?

In your opinion, in what manner has the tested product improved the following skin parameters?

Please give a judgment to the following parameters relative to the tested product.