$1,500
Aging Care Cream
• Summary: “TAM” (＝Telomerase Activating Molecule)
Telomerase Activating Molecules Developed by Sierra Science and mixed with other ingredients for Oral & Dermal products. It shows the”TAM”logo and means those products included Telomerase Activating Molecule or Molecules.
• Product：Tested and Certified by Sierra Science
Aging Care Cream
• Summary: “TAM” (＝Telomerase Activating Molecule)
Telomerase Activating Molecules Developed by Sierra Science and mixed with other ingredients for Oral & Dermal products. It shows the”TAM”logo and means those products included Telomerase Activating Molecule or Molecules.
• Product：Tested and Certified by Sierra Science
Telomeres are an essential part of human cells that affect how our cells age.
As we grow older, telomeres at the end of our chromosomes shrink. New research suggests major depression also is linked to shorter telomeres, a sign of ‘accelerated aging.’
Telomerase, also called telomere terminal transferase,is a ribonycleoprotein that adds the polynucleotide “TTAGGG” to the 3′ end of telomeres, at the ends of eukaryotic chromosomes. It can replace the section of telomere that is lost in each cell divition, so the chromosomes don’t shorten.
Telomere-shortening can be seen as a programmed aging ‘disease’, and could be cured by lengthening telomeres via Telomerase induction.
“TAM-818,” developed by Bill Andrews, Ph. D. (Sierra Sciences, LLC.) in 2014, is a state-of-the-art substance that prevents telomere shortening.
Dr. Bill Andrews began research in 1999, and after investigating nearly 60,000 chemical substances, he finally discovered the first chemical substance with medicinal properties in 2007.
*The patent and product rights for this drug were transferred to the American company T. A. Sciences, and it was introduced into the market as “TA-XX” in 2007.)
He proceeded further verification, discovered C 0314818 after nearly 400,000 verification. It is a substance that has also proved the mechanism in scientific terms and also obtained the patent. It is [Telomerase Activation Molecule] a molecule that induces and activates telomerase [TAM]. Indeed, in comparative tests with “TAM-818” and “TA-XX” found at this time, it is 80 to 300 times more potent than “TA-XX” in telomerase expression that brings about the telomere elongation effect of “TAM-818 Results have also come out.
Studies have also been conducted on nutritional factors for systemic effects, not just telomerase activation of locally segmented cells. It may be beneficial to directly consume telomerase, but this isn’t scientifically possible. Telomerase is not able to survive through digestive process but even if it did, it cannot enter into bloodstream. To solve this problem, Dr. Bill Andrews and his team found a way to activate telomerase, which human body already carries in their system. This substance is called TAM-818. TAM-818 interferes with the action of telomerase inhibiting substances and induces telomerase to function normally and to cause cell division to become more active. This is a result of Dr. Bill Andrews and his team and Sierra Sciences. This can delay human aging and prolong life span and enable you to live a healthier life.
Dr. Bill Andrews and the team at Sierra sciences will continue to research to delay aging and improve healthier lifestyle.
* Warning : If you have or think you may have any serious disease, consult your health care practitioner before using this product. For adults only – not to be taken by people under 25 years of age.
Telomere length change
* Kb: Stands for kilobase, a measurement of DNA length used in genetics.
* MTL: Stands for the median telomere length. This is expressed in Kb or kilobases.
TAM-818 Clinical study of skin application
Bill Andrews, Ph.D., its founder and CEO, is a scientist, athlete and executive. Bill Andrews is one of the principal discoverers of both the RNA and protein components of human telomerase, and was awarded 2nd place as National Inventor of the Year in 1997.
He earned his Ph.D. in Molecular and Population Genetics at the University of Georgia and served as Senior Scientist at Armos Corporation and Codon Corporation, as Molecular Biology Director at Berlex Biosciences and Geron Corporation as well as Director of Technology Development at EOS Biosciences.
In 2007, after years of research, they discovered the world’s first medium-strength telomerase inducer that they labeled COO57684, the 57,684th chemical they tested. This finding confirmed that the team had come up with an accurate, sensitive and fully mechanized high-throughput screening system that worked and allowed the team to accomplish in one day what took months to screen!
The discovery made by the team at SIERRA SCIENCES has numerous applications that can benefit a large variety of needs and challenges.
Among human cell types Skin cells, due to their high renewal rate, are heavily affected by telomere shortening. When our skin’s telomeres get critically short, our cells can no longer reproduce: fine lines, wrinkles, loss of firmness among other signs of aging start to appear.
Defytime Aging Care Cream with the world strongest Telomerase Activating Molecule [TAM]* counteracts and suppresses the fundamental cause of skin aging: telomere shortening. Skin cells are rejuvenated, youthful elasticity is restored, fine lines and wrinkles disappear.
*Developed exclusively for Defytime by Sierra Sciences.
– Looking at the mirror, I began to miss the skin of my twenties.
– I want to be seen younger than the actual age.
– I am interested in the slack of the chin.
– I want to get rid of wrinkles.
– Recently, I am particularly concerned with the line of rail.
– I want to regain skin firmness.
– I want to improve makeup of make-up.
– Beauty treatment is a little scary, so I was looking for other ways.
Bill Andrews, Ph.D., its founder and CEO, is a scientist, athlete and executive. Bill Andrews is one of the principal discoverers of both the RNA and protein components of human telomerase, and was awarded 2nd place as National Inventor of the Year in 1997.
He earned his Ph.D. in Molecular and Population Genetics at the University of Georgia and served as Senior Scientist at Armos Corporation and Codon Corporation, as Molecular Biology Director at Berlex Biosciences and Geron Corporation as well as Director of Technology Development at EOS Biosciences.
In 2007, after years of research, they discovered the world’s first medium-strength telomerase inducer that they labeled COO57684, the 57,684th chemical they tested. This finding confirmed that the team had come up with an accurate, sensitive and fully mechanized high-throughput screening system that worked and allowed the team to accomplish in one day what took months to screen!
The discovery made by the team at SIERRA SCIENCES has numerous applications that can benefit a large variety of needs and challenges.
Among human cell types Skin cells, due to their high renewal rate, are heavily affected by telomere shortening. When our skin’s telomeres get critically short, our cells can no longer reproduce: fine lines, wrinkles, loss of firmness among other signs of aging start to appear.
Defytime Aging Care Cream with the world strongest Telomerase Activating Molecule [TAM]* counteracts and suppresses the fundamental cause of skin aging: telomere shortening. Skin cells are rejuvenated, youthful elasticity is restored, fine lines and wrinkles disappear.
*Developed exclusively for Defytime by Sierra Sciences.
– Looking at the mirror, I began to miss the skin of my twenties.
– I want to be seen younger than the actual age.
– I am interested in the slack of the chin.
– I want to get rid of wrinkles.
– Recently, I am particularly concerned with the line of rail.
– I want to regain skin firmness.
– I want to improve makeup of make-up.
– Beauty treatment is a little scary, so I was looking for other ways.
The feeling of elasticity by moisture is aimed at over 1 month.
The amount to be painted at one time varies depending on the location of application, but please apply as one adapts to the one you care about one push.
You can use one push around 50 days every day using it twice in the morning and the night.
“defytime TAA cream” is not an all-in-one cream, so please use it in conjunction with your current cosmetics. Also, when applying ultrasonic facial equipment or duma roller when applying, cream penetrates deeper, so it is effective.
Since “defytime TAA cream” is fat-soluble, we recommend using it in the order of “lotion” → “beauty essence” → “cream” after cleansing as commonly said with skin cream. Please note that lotion will be played when applying cream first.
It is the first aging care cream to blend the latest telomerase activating molecule [TAM] that was born by Bill Andrews,Ph.D. pioneer of disease treatment by aging by many years of research in the world.
Although there seems to be individual differences, reports from Italy’s “Avici Research Laboratory” conducting various clinical trials such as overseas famous cosmetic manufacturers that the improvement of wrinkles, spots and sagging was confirmed in clinical trials I am receiving.
Please consider one month or more between Hari by moisture.
Because the condition of your skin will change due to seasons and environmental influences, depending on the time it may take several months. We recommend you to continue using it.
“defytime TAA cream” is a product made for the purpose of using for the face and neck, but there is no particular problem even if it is used for other parts.
We recommend twice in the morning and thefternoon.
There is no problem to use it in the order of “lotion” → “beauty essence” → “cream” after washing the face or in general.
Regarding the amount to be applied, I think that it varies depending on the part to be applied, but as a guide, please apply as one push (about 0.5 g), familiar to the anxious part as a guide.
In addition, if ultrasonic facial equipment and duma roller are used together, cream penetrates deeper, so it is effective.
“defytime TAA cream” is a mechanism to induce cell telomerase activity by [TAM].
It is more effective if you use it in combination with your current cosmetic product.
In the clinical trial at the Avici Laboratories, there were no reports of side effects, etc., but please be sure to conduct a patch test before use.
Since this product contains more than 95% of natural ingredients, there is a possibility that ingredients that do not fit your skin are included rarely.
It seems that there are many cases in which it is familiar to your skin by using a small amount of application and using it every few days. Please try once. However, there seem to be cases where symptoms appear due to insufficient sleep, stress, vitamin deficiency etc, so please refrain from using it until your physical condition is recovered, for example when your physical condition is bad.
Please keep away from direct sunlight and high temperature and humid place.
Also, please follow the notes displayed on the product after opening, please use as soon as possible. Should you feel separation, deterioration, discoloration, odor, etc., please refrain from using it.
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We do not prepare samples at present.
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