Deep Skin Express

Rejuvenating Eye Patch
with Telomerase Activation

Deep Skin Express Rejuvenating Eye Patch 0.5g x 5 pairs

$250

Defytime Deep Skin Express powered by ActivLayr technology rapidly delivers active ingredients into the deep dermal layer of the skin for lasting effects.

Our rejuvenating eye patch intensely and instantly firms the skin and fills in deep lines and wrinkles around the eye area. The convenient and fast application is a completely new way to carry out the daily eye treatment ritual.

  • Rapidly delivers active ingredients into the deep dermal layer of the skin for long term rejuvenation
  • Convenient and fast application (1 minute)
  • Over 1.5mm absorption into the dermal layer after 50 minutes
  • Made in New Zealand from 100% natural and sustainable ingredients
  • Dermal tested and hypoallergenic
Category:

ActivLayr technology

A superior skin delivery platform

Most conventional cosmetic creams can not achieve skin penetration beyond the outer stratum corneum barrier of the skin, and may only deliver a small percentage of their active ingredients. Defytime Deep Skin Express powered by ActivLayr technology can achieve deep absorption by passing through the stratum corneum into the dermal layer and deliver 100% of the bioactive (TAM CO314818). This intelligent skin delivery system quickly and efficiently carries the actives to where they can live up to their full potential and work within the skin for long term effects.

Fast and effective application

  1. Lightly spray water onto skin around eye area.
  2. Using dry hands, remove clear plastic cover from eye patch.
  3. Apply white side of patch firmly onto moistened skin under eye.
  4. Wait 1 minute for full absorption before removing patch.
  5. Leave to dry, dab any excess residue with fingers.

Natural ingredients

Sourced from NZ’s pure and clean environment

Marine Collagen

Sourced from deep water fish in New Zealand’s pristine oceans using sustainable practices. Collagen has been widely known and used in the development of cosmetic formulations as a natural moisturizer and provides instant skin tightening due to its natural skin compatibility. Marine collagen is generally considered superior to other forms of collagen due to its high Hydroxyproline and Lysine content which helps to combat skin aging.

Hyaluronic Acid

The gold-standard ingredient for helping the skin retain moisture. Hyaluronic Acid is incorporated into the Deep Skin Express chemistry and gives an added moisturisation benefit.

TAM CO314818

Developed by Bill Andrews, Ph.D. (Sierra Sciences, LLC.) in 2014, TAM CO314818 is a state-of-the-art Telomerase Activating Molecule (TAM) that counteracts and suppresses the fundamental cause of skin aging: telomere shortening. By interfering with the action of telomerase inhibiting substances TAM CO314818 induces telomerase to function normally and to cause cell division to become more active. Skin cells are rejuvenated, youthful elasticity is restored, fine lines and wrinkles disappear.

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The science of ActivLayr

Defytime Deep Skin Express employs ActivLayr technology – a patented skin delivery platform based on the denatured whole chains of type 1 collagen extracted from NZ hoki fish skins.

Collagen extracted from the hoki fish is solubilised with bioactives, and is turned into nanofibre via a proprietary Sonic Electrospinning process. During this process the bioactives are encapsulated or chemically bonded to the nanofibres and attain an even distribution on the matrix. The bioactives remain stable on the matrix during storage, under moisture-free ambient conditions. On exposure to moistened skin, the nanofibres dissolve, thereby releasing the bioactives.

Achieving absorption below the stratum corneum barrier

Usually, proteins of high molecular weight (HMW), such as collagen, cannot be absorbed or pass through the stratum corneum of the skin. They remain on the surface instead, keeping the skin hydrated through water absorption [6, 7] and as protectors against microbial infiltration in cases of wounded tissue. But the moisturizing effect does not last long as it is only superficially absorbed by the stratum corneum of the epidermal layer.

But by delivering the whole chain collagen molecule in the form of a nanofiber matrix, even HMW collagen protein can break up in to small dissolvable pieces to enter the stratum corneum. This base idea is used to construct the patented ActivLayr skin delivery technology which is composed of HMW denatured collagen, low molecular weight (LMW) hydrolysed collagen, and bioactives.

Therefore, a collagen matrix containing a denatured and hydrolysed collagen mix can have a profound effect on skin by delivering the bioactives deeper while integrating into the skin’s own collagen framework to reduce skin wrinkles.

Human skin anatomy

The skin consists of three main layers, from the exterior to interior, the epidermis, the dermis and the hypodermis. The epidermis, in turn, is divided in 4 parts, from the inside to the outside, the stratum basale, stratum spinosum, stratum granulosum and stratum corneum which is in contact with the outside [1, 2].

Stratum corneum (SC) is the largest contributor to the barrier function of the skin which prevents large molecules from passing through [2, 3].

Scientific Analysis

Optical Coherence Tomography (OCT)

Optical Coherence Tomography (OCT) has been proven to be the optimal scientific method for non-invasive and non-destructive functional real-time spectral imaging. Fundamentally, the diffusion of bioactives into a substrate will change its scattering properties which is then detectable by OCT. By utilizing specialized software, double correlation analysis of 2D and 3D OCT images are used for validation of the skin penetration results. The methodology, design and development procedure was scientifically thorough and strategically intended to visualize the bioactives delivery, and penetration into skin tissue.

Skin penetration OCT analysis

The skin of a piglet was chosen for penetration studies due to its physiological and anatomical similarities with human skin, specifically its permeability behavior [1]. For example, the skin layers in both species have a relatively thick epidermis that is separated from all the sublayers. The dermis of both species also contains an abundance of elastic tissue with similar collagen fibril thicknesses [4, 5].

The OCT test was performed by Dr. Azam Ali and his team at Otago University involving the Otago School of Medicine, the bioengineering research team at the Centre for Materials Science & Technology and the Department of Physics.

OCT skin penetration results

At 0 minutes (within 60 seconds), Defytime Deep Skin Express dissolves instantly, passing through the greatest skin barrier (stratum corneum). At 50 minutes, the bioactives reach over 1.5mm within the deep dermal layer.

OCT skin penetration images

These images show the penetration of bioactives within the skin layer after Defytime Deep Skin Express application, demonstrating deep absorption of actives diffusing across the skin layer. Image A represents the application at 0 minutes (within 60 seconds), whereas image B represents the skin 50 minutes after application. We can see that there is a consistent distribution of actives, as well as no signs of agglomerations. Images C and D help visually enhance the penetration effect of the actives of A and B, respectively.

OCT skin penetration results

At 0 minutes (within 60 seconds), Defytime Deep Skin Express dissolves instantly, passing through the greatest skin barrier (stratum corneum). At 50 minutes, the bioactives reach over 1.5mm within the deep dermal layer.

OCT skin penetration images

These images show the penetration of bioactives within the skin layer after Defytime Deep Skin Express application, demonstrating deep absorption of actives diffusing across the skin layer. Image A represents the application at 0 minutes (within 60 seconds), whereas image B represents the skin 50 minutes after application. We can see that there is a consistent distribution of actives, as well as no signs of agglomerations. Images C and D help visually enhance the penetration effect of the actives of A and B, respectively.

Based on the observations of the penetration behaviour represented in the OCT graphs,

Defytime Deep Skin Express with ActivLayr technology will deliver bioactives in less than one minute, and continue penetration for an additional 50 minutes to reach over 1.5 mm into the deep dermal layer of the skin.

This intelligent skin delivery technology which is water based and 100% natural has proved to outperform all cream based cosmetic formulations with respect to penetration time, level and effect without uses of physical enhancement methods. To our knowledge and literature research no skincare cosmetic has claimed such deeper penetration of actives. It is perhaps one of the fastest non-invasive active skin delivery systems in the world.

References
  1. Zaman, N., Influence of the (Ultra) Structure of Skin Specimens used for Pharmacological Studies on the Tissue Permeability, in Department of Pharmaceutics, Laboratory for Medicinal Chemistry. 2014, Universiteit Gent: Belgium.
  2. Mark R Prausnitz , P.M.E., Thomas J Franz , Matthias Schmuth , Jui-Chen Tsai ,Gopinathan K Menon , Walter M Holleran and Kenneth R Feingold, Skin Barrier and Transdermal Drug Delivery, in Medical Therapy. 2012. p. 2065-2073.
  3. R.H.H., T.H.N., Overcoming the Stratum Corneum: The Modulation of Skin Penetration. Skin Pharmacol Appl Skin Physiol, 2006. 19: p. 106-121.
  4. Abd, E., et al., Skin Models for the Testing of Transdermal Drugs. Clinical Pharmacology: Advances and Applications, 2016. 8: p. 163-176.
  5. Dick, I.P. and R.C. Scott, Pig Ear Skin as an In-vitro Model for Human Skin Permeability. Journal of Pharmacy and Pharmacology, 1992. 44(8): p. 640-645.
  6. Alves, A., et al., Cosmetic Potential of Marine Fish Skin Collagen. Cosmetics, 2017. 4(4): p. 39.
  7. Swatschek, D., et al., Marine Sponge Collagen: isolation, characterization and effects on the skin parameters surface-pH, moisture and sebum. European Journal of Pharmaceutics and Biopharmaceutics, 2002. 53(1): p. 107-113.

Bill Andrews, Ph.D.
CEO of Sierra Sciences / R&D for Defytime

Our cutting edge research is led by Dr. Bill Andrews. Dr. Andrews has worked in the biotech industry for over 35 years, focusing the last 20 years on finding ways to extend human lifespan through the intervention of telomere shortening in human cells.

Learn more about Dr. Bill Andrews

Bill Andrews, Ph.D.
CEO of Sierra Sciences / R&D for Defytime

Our cutting edge research is led by Dr. Bill Andrews. Dr. Andrews has worked in the biotech industry for over 35 years, focusing the last 20 years on finding ways to extend human lifespan through the intervention of telomere shortening in human cells.

Learn more about Dr. Bill Andrews

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